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Article

CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by proline-rich stretch-4 of the CD2 cytoplasmic tail.

International immunology - 1 Jul 1998

King P D, Sadra A, Teng J M, Bell G M, Dupont B

Abstract excerpt

Ligation of the CD2 co-stimulatory receptor on human T lymphocytes induces tyrosine phosphorylation and activation of the Tec-family tyrosine kinase, ITK. To examine whether any of several proline-rich (PR) stretches of the CD2 cytoplasmic tail are necessary for ITK activation we introduced wild-...

Topics

Animals
CD2 Antigens
Cytoplasm
Enzyme Activation
Humans
Interleukin-2
Leukemia, T-Cell
Mutation
Peptides
Phosphorylation
Proline-Rich Protein Domains
Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Structure-Activity Relationship

Transfection

Source

Identifiers

PMID: 9701039
DOI: 10.1093/intimm/10.7.1009

Genes

ITK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9701039-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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