Article
Involvement of the PPPGHR motif in T cell activation via CD2.
The Journal of experimental medicine - 1 Jul 1990
Chang H C, Moingeon P, Pedersen R, Lucich J, Stebbins C, Reinherz E L
Abstract excerpt
Prior studies identified a segment of the CD2 cytoplasmic domain between amino acid (aa) residues 253 and 287 as important in T lymphocyte signal transduction. This region contains two repeats of the sequence motif PPPGHR, thought to form a "cage" structure involved in CD2-mediated signaling. To...
Topics
- Amino Acid Sequence
- Amino Acids
- Animals
- Antigens, Differentiation, T-Lymphocyte
- Base Sequence
- CD2 Antigens
- Calcium
- Cell Line
- DNA
- Gene Expression
- Humans
- Interleukin-2
- Lymphocyte Activation
- Mice
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Receptors, Immunologic