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Article

Involvement of the PPPGHR motif in T cell activation via CD2.

The Journal of experimental medicine - 1 Jul 1990

Chang H C, Moingeon P, Pedersen R, Lucich J, Stebbins C, Reinherz E L

Abstract excerpt

Prior studies identified a segment of the CD2 cytoplasmic domain between amino acid (aa) residues 253 and 287 as important in T lymphocyte signal transduction. This region contains two repeats of the sequence motif PPPGHR, thought to form a "cage" structure involved in CD2-mediated signaling. To evaluate this segment, a series of mutant human CD2 molecules were produced by oligonucleotide-directed mutagenesis and...

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Identifiers

PMID: 1972730
DOI: 10.1084/jem.172.1.351
PMCID: PMC2188155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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