Article
Abnormal deletions in the T-cell receptor delta locus of mouse thymocytes.
Molecular and cellular biology - 1 Jul 1994
Fish S M, Bosma M J
Abstract excerpt
Separate genetic elements (V, D, and J) encode the variable regions of lymphocyte antigen receptors. During early lymphocyte differentiation, these elements rearrange to form contiguous coding segments (VJ and VDJ) for a diverse array of variable regions. Rearrangement is mediated by a recombinas...
Topics
- Aging
- Animals
- Animals, Newborn
- Base Sequence
- Cell Differentiation
- DNA
- Embryonic and Fetal Development
- Gene Deletion
- Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
- Genetic Variation
- Mice
- Mice, Inbred Strains
- Mice, SCID
- Molecular Sequence Data
- Receptors, Antigen, T-Cell, gamma-delta
- Species Specificity
- T-Lymphocytes
- Thymus Gland