The 5A/6A polymorphism in the promoter of the stromelysin-1 (MMP-3) gene predicts progression of angiographically determined coronary artery disease in men in the LOCAT gemfibrozil study. Lopid Coronary Angiography Trial.

doi:10.1016/s0021-9150(98)00053-7

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Article

The 5A/6A polymorphism in the promoter of the stromelysin-1 (MMP-3) gene predicts progression of angiographically determined coronary artery disease in men in the LOCAT gemfibrozil study. Lopid Coronary Angiography Trial.

Atherosclerosis - 1 Jul 1998

Humphries S E, Luong L A, Talmud P J, Frick M H, Kesäniemi Y A, Pasternack A, Taskinen M R, Syvänne M

Abstract excerpt

The relationship between the 5A/6A stromelysin-1 promoter polymorphism and progression of angiographically determined coronary artery disease (CAD) has been examined in men treated for 32 months with gemfibrozil or placebo in the Lopid Coronary Angiography Trial (LOCAT). The frequency of the 5A a...

Topics

Aged
Coronary Angiography
Coronary Disease
Disease Progression
Double-Blind Method
Gemfibrozil
Genotype
Humans
Hypolipidemic Agents
Male
Matrix Metalloproteinase 3
Middle Aged
Promoter Regions, Genetic

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PMID: 9699891
DOI: 10.1016/s0021-9150(98)00053-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9699891-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.