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Article

Progression of atherosclerosis is associated with variation in the alpha1-antitrypsin gene.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2003

Talmud Philippa J, Martin Steve, Steiner George, Flavell David M, Whitehouse David B, Nagl Sylvia, Jackson Richard, Taskinen Marja-Riitta, Frick M Heikki, Nieminen Markku S, Kesäniemi Y Antero, Pasternack Amos, Humphries Steve E, Syvänne Mikko

Abstract excerpt

OBJECTIVE: Alpha1-Antitrypsin (AAT) protects elastic tissue and may play a role in atherogenesis. The association of atherosclerosis progression with common AAT variants was considered in 2 clinical trials. METHODS AND RESULTS: We examined the association of AAT V213A, S and Z deficiency alleles, and the functional 3' UTR 11478G>A with change in minimal luminal diameter, a measure of focal disease, in the Lopid...

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Identifiers

PMID: 12692006
DOI: 10.1161/01.ATV.0000065196.61663.8D

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Source receipt: pubmed, retrieved 7 Sept 2026.

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