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Article

DAMGO recognizes four residues in the third extracellular loop to discriminate between mu- and kappa-opioid receptors.

European journal of pharmacology - 5 Jun 1998

Seki T, Minami M, Nakagawa T, Ienaga Y, Morisada A, Satoh M

Abstract excerpt

Previously, we reported that replacement of the region from the fifth transmembrane domain to the C-terminus of kappa-opioid receptor with the corresponding region of mu-opioid receptor gives high affinity for [D-Ala2, N-MePhe4, Gly-ol5]enkephalin (DAMGO), a mu-opioid receptor-selective ligand, to the resultant chimeric receptor, suggesting that the difference in the amino acid sequence within this region is...

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Identifiers

PMID: 9696421
DOI: 10.1016/s0014-2999(98)00240-4

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