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Article

A conserved arginine in the distal third intracellular loop of the mu-opioid receptor is required for G protein activation.

Journal of neurochemistry - 1 Mar 1999

Wang H L

Abstract excerpt

In the present study, the functional significance of the intracellular C-terminal loop of the mu-opioid receptor in activating Gi proteins was determined by constructing a C-terminal deletion mutant mu(C delta 45) receptor, which lacks the carboxyl 45 amino acids. When the truncated mu(C delta 45) receptor was stably expressed in human embryonic kidney (HEK) 293 cells, the efficacy and the potency of...

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PMID: 10037504
DOI: 10.1046/j.1471-4159.1999.0721307.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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