Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction of p-fluorofentanyl on cloned human opioid receptors and exploration of the role of Trp-318 and His-319 in mu-opioid receptor selectivity.

The Journal of pharmacology and experimental therapeutics - 1 Sept 2000

Ulens C, Van Boven M, Daenens P, Tytgat J

Abstract excerpt

In this study, we investigated the interactions of p-fluorofentanyl, an opioid designer drug, fentanyl, sufentanyl, and morphine on cloned human mu-, kappa-, and delta-opioid receptors coexpressed with heteromultimeric G protein-coupled inwardly rectifying K(+) channels (GIRK1/GIRK2) and a regulator of G protein signaling (RGS4) in Xenopus oocytes. We demonstrate that p-fluorofentanyl more potently activates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fentanyl
Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Morphine

Share to Narcotics

Share to Piperidines

Share to Receptors, Opioid, delta

Share to Receptors, Opioid, kappa

Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 10945855

Genes

RGS4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction of p-fluorofentanyl on cloned human opioid receptors and exploration of the role of Trp-318 and His-319 in mu-opioid receptor selectivity.PMID 10945855Read ↗

Determinants of ligand selectivity at the kappa-receptor based on the structure of the orphanin FQ receptor.Semantic proximity Read ↗

beta-Funaltrexamine, a gauge for the recognition site of wildtype and mutant H297Q mu-opioid receptors.Semantic proximity Read ↗

The role of the hydrophilic Asn230 residue of the mu-opioid receptor in the potency of various opioid agonists.Semantic proximity Read ↗

Key residues defining the mu-opioid receptor binding pocket: a site-directed mutagenesis study.Semantic proximity Read ↗

Probing the molecular basis of hERG drug block with unnatural amino acids.Semantic proximity Read ↗

Functional characterization of human variants of the mu-opioid receptor gene.Semantic proximity Read ↗

Mutation of a conserved serine in TM4 of opioid receptors confers full agonistic properties to classical antagonists.Semantic proximity Read ↗

Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid binding cavity.Semantic proximity Read ↗

DAMGO recognizes four residues in the third extracellular loop to discriminate between mu- and kappa-opioid receptors.Semantic proximity Read ↗

The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs.Semantic proximity Read ↗

A6V polymorphism of the human μ-opioid receptor decreases signalling of morphine and endogenous opioids in vitro.Semantic proximity Read ↗

Subtype-selective antagonism of N-methyl-D-aspartate receptors by felbamate: insights into the mechanism of action.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.