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Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects.

PLoS genetics - 1 Dec 2007

Jopling Chris, van Geemen Daphne, den Hertog Jeroen

Abstract excerpt

Shp2 is a cytoplasmic protein-tyrosine phosphatase that is essential for normal development. Activating and inactivating mutations have been identified in humans to cause the related Noonan and LEOPARD syndromes, respectively. The cell biological cause of these syndromes remains to be determined. We have used the zebrafish to assess the role of Shp2 in early development. Here, we report that morpholino-mediated...

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Gastrulation
Gene Targeting
LEOPARD Syndrome
Noonan Syndrome
Protein Tyrosine Phosphatase, Non-Receptor Type 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-fyn

rhoA GTP-Binding Protein

Zebrafish Proteins

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Identifiers

PMID: 18159945
DOI: 10.1371/journal.pgen.0030225
PMCID: PMC2151089

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