Article
Strong influence of human leukocyte antigen-DP variants on response to hepatitis B vaccine in a Japanese population.
Vaccine - 9 Oct 2017
Okada Yuya, Uno Naoki, Sato Shuntaro, Mori Sayaka, Sasaki Daisuke, Kaku Norihito, Kosai Kosuke, Morinaga Yoshitomo, Hasegawa Hiroo, Yanagihara Katsunori
Abstract excerpt
Genome-wide association studies (GWASs) have reported that human leukocyte antigen (HLA) variants are associated with chronic hepatitis B, spontaneous hepatitis B virus (HBV) clearance, and response to hepatitis B vaccine. Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV...
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