Identification of amino acids in antigen-binding site of class II HLA proteins independently associated with hepatitis B vaccine response

doi:10.1016/j.vaccine.2016.08.068

Article

Identification of amino acids in antigen-binding site of class II HLA proteins independently associated with hepatitis B vaccine response

30 Dec 2016

Abstract excerpt

BACKGROUND & AIMS: Genetic factors in class II human leukocyte antigen (HLA) have been reported to be associated with inter-individual variation in hepatitis B virus (HBV) vaccine response. However, the mechanism underlying the associations remains elusive. In particular, the broad linkage disequilibrium in HLA region complicates the localization of the independent effects of genetic variants. Thus, the present...

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