Familial psoriasis and HLA-B: unambiguous support for linkage in 97 published families.

doi:10.1159/000022802

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Article

Familial psoriasis and HLA-B: unambiguous support for linkage in 97 published families.

Human heredity - 1 Jan 2000

Leder R O, Mansbridge J N, Hallmayer J, Hodge S E

Abstract excerpt

The existence of a psoriasis susceptibility locus, PSORS1 (HUGO/GDB-approved symbol), in or near the HLA region of chromosome 6 is strongly supported by a lod score analysis of HLA-B and psoriasis in 97 families from 16 published datasets. Families included in the dataset represent all the psoria...

Topics

Alleles
Chromosomes, Human, Pair 6
Genetic Linkage
Genetic Variation
HLA-B Antigens
Haplotypes
Humans
Linkage Disequilibrium
Lod Score
Models, Genetic
Pedigree
Psoriasis

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