Article
Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan.
Human molecular genetics - 1 Aug 1997
Nair R P, Henseler T, Jenisch S, Stuart P, Bichakjian C K, Lenk W, Westphal E, Guo S W, Christophers E, Voorhees J J, Elder J T
Abstract excerpt
In a 12.5 cM genome-wide scan for psoriasis susceptibility loci, recombination-based tests revealed linkage to the HLA region (Zmax = 3.52), as well as suggestive linkage to two novel regions: chromosome 16q (60-83.1 cM from pter, Zmax = 2.50), and chromosome 20p (7.5-25 cM from pter, Zmax = 2.62). All three regions yielded P values < or = 0.01 by non-parametric analysis. Recombination-based and allele sharing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
