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Article

PU.1 regulates the expression of the human neutrophil elastase gene.

Biochimica et biophysica acta - 16 Jun 1998

Srikanth S, Rado T A

Abstract excerpt

PU.1 is a transcription factor present in B-cells and macrophages. Here, we report our studies on the role of PU.1 in myelopoiesis using human neutrophil elastase (HNE) as a model. HNE, a component of the primary granules of mature granulocytes, is a serine protease which is transcriptionally restricted to the late promyelocytic stage of granulocytic maturation. The first 200 bp of the HNE promoter directs...

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PMID: 9689920
DOI: 10.1016/s0167-4781(98)00039-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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PU.1 regulates the expression of the human neutrophil elastase gene.PMID 9689920Read ↗

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