PU.1 regulates the expression of the human neutrophil elastase gene.

doi:10.1016/s0167-4781(98)00039-6

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Article

PU.1 regulates the expression of the human neutrophil elastase gene.

Biochimica et biophysica acta - 16 Jun 1998

Srikanth S, Rado T A

Abstract excerpt

PU.1 is a transcription factor present in B-cells and macrophages. Here, we report our studies on the role of PU.1 in myelopoiesis using human neutrophil elastase (HNE) as a model. HNE, a component of the primary granules of mature granulocytes, is a serine protease which is transcriptionally res...

Topics

Amino Acid Substitution
Antibodies
Binding Sites
Cell Extracts
DNA
DNA-Binding Proteins
Electrophoresis, Polyacrylamide Gel
Gene Expression
Gene Expression Regulation
Gene Expression Regulation, Enzymologic
Genes
HeLa Cells
Humans
Leukocyte Elastase
Mutation
Phosphoric Monoester Hydrolases
Phosphorylation
Promoter Regions, Genetic

Source

Open in PubMed

Identifiers

PMID: 9689920
DOI: 10.1016/s0167-4781(98)00039-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9689920-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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