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Article

LEF-1 is a decisive transcription factor in neutrophil granulopoiesis.

Annals of the New York Academy of Sciences - 1 Jun 2007

Skokowa Julia, Welte Karl

Abstract excerpt

We found that lymphoid enhancer-binding factor 1 (LEF-1) is a decisive transcription factor in granulopoiesis controlling proliferation, proper lineage commitment, and granulocytic differentiation via regulation of its target genes C/EBP-alpha, cyclin D1, c-myc, and survivin. Myeloid progenitor cells of patients with severe congenital neutropenia (CN) showed a severe downregulation of LEF-1 and its target genes...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17360796
DOI: 10.1196/annals.1392.012

Genes

EBP

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