Article
Transcription of the IL10 gene reveals allele-specific regulation at the mRNA level.
Human molecular genetics - 15 Aug 2004
Kurreeman Fina A S, Schonkeren Joris J M, Heijmans Bastiaan T, Toes Rene E M, Huizinga Tom W J
Abstract excerpt
Interleukin-10 (IL10) is a cytokine with key regulatory and anti-inflammatory function involved in the pathogenesis of various diseases. Although the large interindividual differences in the production of IL10 have been extensively associated with polymorphisms and haplotypes of the IL10 gene, surprisingly little evidence exists that this variation is actually dictated by IL10 haplotypes. Using the technique of...
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