Linkage of HLA to myasthenia gravis and genetic heterogeneity depending on anti-titin antibodies.

doi:10.1212/wnl.57.9.1555

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Article

Linkage of HLA to myasthenia gravis and genetic heterogeneity depending on anti-titin antibodies.

Neurology - 13 Nov 2001

Giraud M, Beaurain G, Yamamoto A M, Eymard B, Tranchant C, Gajdos P, Garchon H J

Abstract excerpt

BACKGROUND: MG is an autoimmune disease of the neuromuscular junction. MG with thymus hyperplasia has been associated with, but not genetically linked to, the HLA-DR3 haplotype. OBJECTIVE: To re-evaluate the association of HLA with MG in 656 patients with generalized disease and to test linkage of HLA to MG with thymus hyperplasia. METHOD: Patients were genotyped for HLA-DRB1. Data analysis included case-control...

Topics

Adult
Autoantibodies
Case-Control Studies
Connectin
Female
Genetic Heterogeneity
Genotype
HLA-DR Antigens
HLA-DR3 Antigen
HLA-DRB1 Chains
Humans
Linkage Disequilibrium
Male
Muscle Proteins
Myasthenia Gravis
Phenotype
Protein Kinases
Thymus Gland

Source

Open in PubMed

Identifiers

PMID: 11706089
DOI: 10.1212/wnl.57.9.1555

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