Article
Linkage of HLA to myasthenia gravis and genetic heterogeneity depending on anti-titin antibodies.
Neurology - 13 Nov 2001
Giraud M, Beaurain G, Yamamoto A M, Eymard B, Tranchant C, Gajdos P, Garchon H J
Abstract excerpt
BACKGROUND: MG is an autoimmune disease of the neuromuscular junction. MG with thymus hyperplasia has been associated with, but not genetically linked to, the HLA-DR3 haplotype. OBJECTIVE: To re-evaluate the association of HLA with MG in 656 patients with generalized disease and to test linkage of HLA to MG with thymus hyperplasia. METHOD: Patients were genotyped for HLA-DRB1. Data analysis included case-control...
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