Article
Effects of mutations in GrlA of topoisomerase IV from Staphylococcus aureus on quinolone and coumarin activity.
Antimicrobial agents and chemotherapy - 1 Aug 1998
Fournier B, Hooper D C
Abstract excerpt
The grlA genes of Staphylococcus aureus ISP794 (wild type), MT5224c4 (grlA [Phe-80]), MT5224c2 (grlA [Pro-116]), and MT111 (grlA [Glu-116]) were cloned in pSK950, a shuttle vector, and introduced into S. aureus strains derived from strain RN4220. The mutations at position 116 of GrlA (Ala-->Pro o...
Topics
- Alleles
- Anti-Infective Agents
- Coumarins
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Fluoroquinolones
- Mutation
- Staphylococcus aureus