The nuoM arg368his mutation in NADH:ubiquinone oxidoreductase from Rhodobacter capsulatus: a model for the human nd4-11778 mtDNA mutation associated with Leber's hereditary optic neuropathy.

doi:10.1016/s0925-4439(98)00036-2

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Article

The nuoM arg368his mutation in NADH:ubiquinone oxidoreductase from Rhodobacter capsulatus: a model for the human nd4-11778 mtDNA mutation associated with Leber's hereditary optic neuropathy.

Biochimica et biophysica acta - 14 Aug 1998

Lunardi J, Darrouzet E, Dupuis A, Issartel J P

Abstract excerpt

Mutation at position 11778 in the nd4 gene of the human mitochondrial complex I is associated with Leber's hereditary optic neuropathy. Type I NADH:ubiquinone oxidoreductase of Rhodobacter capsulatus displays similar properties to complex I of the mitochondrial respiratory chain. The NUOM subunit...

Topics

Amino Acid Sequence
Bacterial Proteins
Cell Division
DNA, Mitochondrial
Electron Transport Complex I
Genotype
Humans
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
NAD(P)H Dehydrogenase (Quinone)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

NADH, NADPH Oxidoreductases

Optic Atrophies, Hereditary

Oxidative Phosphorylation

Oxygen Consumption

Phenotype

Proton Pumps

Rhodobacter capsulatus

Source

Open in PubMed

Identifiers

PMID: 9685604
DOI: 10.1016/s0925-4439(98)00036-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9685604-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The nuoM arg368his mutation in NADH:ubiquinone oxidoreductase from Rhodobacter capsulatus: a model for the human nd4-11778 mtDNA mutation associated with Leber's hereditary optic neuropathy.PMID 9685604Read ↗

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