Article
Electron transfer properties of NADH:ubiquinone reductase in the ND1/3460 and the ND4/11778 mutations of the Leber hereditary optic neuroretinopathy (LHON).
FEBS letters - 4 Nov 1991
Majander A, Huoponen K, Savontaus M L, Nikoskelainen E, Wikström M
Abstract excerpt
We report the electron transfer properties of the NADH:ubiquinone oxidoreductase complex of the respiratory chain (Complex I) in mitochondria of cells derived from LHON patients with two different mutations in mitochondrial DNA (mtDNA). The mutations occur in the mtDNA genes coding for the ND1 an...
Topics
- DNA, Mitochondrial
- Electron Transport
- Humans
- Intracellular Membranes
- Mutation
- NAD(P)H Dehydrogenase (Quinone)
- NADH Dehydrogenase
- Optic Atrophies, Hereditary
- Oxidation-Reduction
- Substrate Specificity