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Article

The clinically relevant triple mutation in the mtND1 gene inactivates Escherichia coli complex I.

FEBS letters - 1 May 2022

Hoeser Franziska, Weiß Maximilian, Friedrich Thorsten

Abstract excerpt

NADH:ubiquinone oxidoreductase (respiratory complex I) plays a major role in cellular energy metabolism. Complex I deficiencies are the most common cause of mitochondrial dysfunction. Patients suffering from a variety of neurodegenerative diseases carry numerous mutations in the mitochondrially encoded subunits of the complex. The biochemical consequences of these mutations are largely unknown because these genes...

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PMID: 35234296
DOI: 10.1002/1873-3468.14325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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