Article
Respiration and growth defects in transmitochondrial cell lines carrying the 11778 mutation associated with Leber's hereditary optic neuropathy.
The Journal of biological chemistry - 31 May 1996
Hofhaus G, Johns D R, Hurko O, Attardi G, Chomyn A
Abstract excerpt
Mitochondrial DNA from two genetically unrelated patients carrying the mutation at position 11778 that causes Leber's hereditary optic neuropathy has been transferred with mitochondria into human mtDNA-less rho0206 cells. As analyzed in several transmitochondrial cell lines thus obtained, the mut...
Topics
- Adult
- Cell Division
- Cell Line
- Cell Line, Transformed
- DNA, Mitochondrial
- Electron Transport
- Humans
- Male
- Middle Aged
- Mitochondria
- Mutation
- NAD(P)H Dehydrogenase (Quinone)
- NADH Dehydrogenase
- Optic Atrophies, Hereditary
- Oxidative Phosphorylation
- Oxygen