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Article

Biochemical consequences of two clinically relevant ND-gene mutations in Escherichia coli respiratory complex I.

Scientific reports - 16 Jun 2021

Nuber Franziska, Schimpf Johannes, di Rago Jean-Paul, Tribouillard-Tanvier Déborah, Procaccio Vincent, Martin-Negrier Marie-Laure, Trimouille Aurélien, Biner Olivier, von Ballmoos Christoph, Friedrich Thorsten

Abstract excerpt

NADH:ubiquinone oxidoreductase (respiratory complex I) plays a major role in energy metabolism by coupling electron transfer from NADH to quinone with proton translocation across the membrane. Complex I deficiencies were found to be the most common source of human mitochondrial dysfunction that manifest in a wide variety of neurodegenerative diseases. Seven subunits of human complex I are encoded by mitochondrial...

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PMID: 34135385
DOI: 10.1038/s41598-021-91631-3
PMCID: PMC8209014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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