Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase.

doi:10.1074/jbc.273.32.20551

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Article

Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase.

The Journal of biological chemistry - 7 Aug 1998

Darnay B G, Haridas V, Ni J, Moore P A, Aggarwal B B

Abstract excerpt

Various members of the tumor necrosis factor (TNF) receptor superfamily interact directly with signaling molecules of the TNF receptor-associated factor (TRAF) family to activate nuclear factor kappaB (NF-kappaB) and the c-Jun N-terminal kinase (JNK) pathway. The receptor activator of NF-kappaB (...

Topics

Amino Acid Sequence
Bacterial Proteins
Calcium-Calmodulin-Dependent Protein Kinases
Carrier Proteins
Cells, Cultured
Enzyme Activation
Gene Expression Regulation
Humans
JNK Mitogen-Activated Protein Kinases
Membrane Glycoproteins
Membrane Proteins
Mitogen-Activated Protein Kinases

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Molecular Sequence Data

Mutation

NF-kappa B

Protein Binding

RANK Ligand

Receptor Activator of Nuclear Factor-kappa B

Source

Open in PubMed

Identifiers

PMID: 9685412
DOI: 10.1074/jbc.273.32.20551

Genes

TNF
TRAF2
TRAF5
TRAF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9685412-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.