Article
The -514 polymorphism in the hepatic lipase gene (LIPC) does not influence androgen-mediated stimulation of hepatic lipase activity.
Journal of lipid research - 1 Jul 1998
Vega G L, Gao J, Bersot T P, Mahley R W, Verstraete R, Grundy S M, White A, Cohen J C
Abstract excerpt
The -514T allele of hepatic lipase is associated with increased high density lipoprotein-cholesterol levels in men, but not in women. This observation suggests that the -514C to T polymorphism may diminish the response of hepatic lipase to androgens. To test this hypothesis, five -514T and five -...
Topics
- Adult
- Alleles
- Anabolic Agents
- Female
- Genotype
- Homozygote
- Humans
- Lipase
- Liver
- Luciferases
- Male
- Metribolone
- Middle Aged
- Polymorphism, Genetic
- Premenopause
- Promoter Regions, Genetic
- Reference Values
- Sex Characteristics