Article
Bone morphogenetic protein 2 suppresses the transformed phenotype and restores actin microfilaments of human lung carcinoma A549 cells.
Oncology reports - 1 Jan 2000
Tada A, Nishihara T, Kato H
Abstract excerpt
Bone morphogenetic protein 2 (BMP2) is a member of the transforming growth factor beta (TGFbeta) superfamily. Here we report a biological function of BMP2. Treatment of human lung carcinoma cell line, A549 cells with BMP2 resulted in inhibition of A549 cell growth in anchorage-dependent and indep...
Topics
- Actin Cytoskeleton
- Actins
- Activins
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Proteins
- Cell Adhesion
- Cell Division
- Cell Transformation, Neoplastic
- Growth Substances
- Humans
- Inhibins
- Lung Neoplasms
- Phenotype
- Transforming Growth Factor beta
- Tumor Cells, Cultured