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Article

Methotrexate-Induced Epithelial-Mesenchymal Transition in the Alveolar Epithelial Cell Line A549.

Lung - 1 Dec 2016

Kawami Masashi, Harabayashi Rika, Miyamoto Mioka, Harada Risako, Yumoto Ryoko, Takano Mikihisa

Abstract excerpt

PURPOSE: Methotrexate (MTX) therapy of certain cancers and rheumatoid arthritis often induces serious interstitial lung complications including pulmonary fibrosis. In this study, we investigated the epithelial-mesenchymal transition (EMT) induced by MTX and by transforming growth factor (TGF)-β1 in the human alveolar epithelial cell line A549 in order to develop new strategies for the prevention of EMT. METHODS:...

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Identifiers

PMID: 27604426
DOI: 10.1007/s00408-016-9935-7

Genes

SMAD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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