Article
Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13.
American journal of human genetics - 1 Aug 1998
Nakagawa Y, Kawaguchi Y, Twells R C, Muxworthy C, Hunter K M, Wilson A, Merriman M E, Cox R D, Merriman T, Cucca F, McKinney P A, Shield J P, Tuomilehto J, Tuomilehto-Wolf E, Ionesco-Tirgoviste C, Nisticò L, Buzzetti R, Pozzilli P, Joner G, Thorsby E, Undlien D E, Pociot F, Nerup J, Rönningen K S, Bain S C, Todd J A
Abstract excerpt
Genomewide linkage studies of type 1 diabetes (or insulin-dependent diabetes mellitus [IDDM]) indicate that several unlinked susceptibility loci can explain the clustering of the disease in families. One such locus has been mapped to chromosome 11q13 (IDDM4). In the present report we have analyzed 707 affected sib pairs, obtaining a peak multipoint maximum LOD score (MLS) of 2.7 (lambda(s)=1.09) with linkage...
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