Article
Genetic analysis of the cytochrome P450 CYP2D6 polymorphism in patients with systemic lupus erythematosus.
Pharmacogenetics - 1 Jun 1998
Sabbagh N, Marez D, Queyrel V, Lo Guidice J M, Spire C, Vanhille P, Jörgensen C, Hachulla E, Broly F
Abstract excerpt
Previous reports of an association between the polymorphic cytochrome P450 CYP2D6 and systemic lupus erythematosus are conflicting. Following the elucidation of the molecular basis of the CYP2D6 genetic polymorphism, we re-examined the hypothesis of an association of this gene with a susceptibility to system lupus erythematosus by analysing the complete CYP2D6 coding sequence. For this purpose, we studies the...
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