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Article

Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways.

Experimental neurology - 1 Jul 1998

Velier J, Kim M, Schwarz C, Kim T W, Sapp E, Chase K, Aronin N, DiFiglia M

Abstract excerpt

Huntingtin is a cytoplasmic protein that is found in neurons and somatic cells. In patients with Huntington's disease (HD), the NH2-terminal region of huntingtin has an expanded polyglutamine tract. An abnormal protein interaction by mutant huntingtin has been proposed as a mechanism for HD pathogenesis. Huntingtin associates with vesicle membranes and interacts with proteins involved in vesicle trafficking. It...

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Identifiers

PMID: 9682010
DOI: 10.1006/exnr.1998.6832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways.PMID 9682010Read ↗

Hypothesis: huntingtin may function in membrane association and vesicular traffickingThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Membrane Proteins in Health and Disease.Semantic proximity Read ↗

Mutant huntingtin regulates EGF receptor fate in non-neuronal cells lacking wild-type protein.Semantic proximity Read ↗

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons.Semantic proximity Read ↗

Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo.Semantic proximity Read ↗

Wild-type huntingtin plays a role in brain development and neuronal survival.Semantic proximity Read ↗

Synaptic dysfunction in Huntington's disease: a new perspective.Semantic proximity Read ↗

Multiple pathways contribute to the pathogenesis of Huntington disease.Semantic proximity Read ↗

Polyglutamine expansion in huntingtin alters its interaction with phospholipids.Semantic proximity Read ↗

Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatus.Semantic proximity Read ↗

Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway.Semantic proximity Read ↗

Mutant huntingtin affects endocytosis in striatal cells by altering the binding of AP-2 to membranes.Semantic proximity Read ↗

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease.Semantic proximity Read ↗

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