Article
Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways.
Experimental neurology - 1 Jul 1998
Velier J, Kim M, Schwarz C, Kim T W, Sapp E, Chase K, Aronin N, DiFiglia M
Abstract excerpt
Huntingtin is a cytoplasmic protein that is found in neurons and somatic cells. In patients with Huntington's disease (HD), the NH2-terminal region of huntingtin has an expanded polyglutamine tract. An abnormal protein interaction by mutant huntingtin has been proposed as a mechanism for HD patho...
Topics
- Alleles
- Animals
- Blotting, Western
- Brain Chemistry
- Cells, Cultured
- Clathrin
- Endocytosis
- Fibroblasts
- Humans
- Huntingtin Protein
- Immunohistochemistry
- Microscopy, Confocal
- Mutation
- Nerve Tissue Proteins
- Nuclear Proteins
- Rats
- Subcellular Fractions
- Synaptic Vesicles