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Article

Mutant huntingtin affects endocytosis in striatal cells by altering the binding of AP-2 to membranes.

Experimental neurology - 1 Mar 2013

Borgonovo Janina E, Troncoso Mariana, Lucas José J, Sosa Miguel A

Abstract excerpt

Clathrin-mediated endocytosis plays an important role in the maintenance of neuronal integrity in the synaptic terminals. Here we studied the effect of anomalous polyglutamine expansion in huntingtin on the interaction of coat proteins with membranes, in areas of mouse brain or in cultured striat...

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Source

Identifiers

PMID: 23219902
DOI: 10.1016/j.expneurol.2012.11.025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23219902-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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Mutant huntingtin affects endocytosis in striatal cells by altering the binding of AP-2 to membranes.PMID 23219902Read ↗

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Polyglutamine expansion in huntingtin alters its interaction with phospholipids.Semantic proximity Read ↗

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