Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons.

doi:10.1016/0896-6273(95)90346-1

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Article

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons.

Neuron - 1 May 1995

DiFiglia M, Sapp E, Chase K, Schwarz C, Meloni A, Young C, Martin E, Vonsattel J P, Carraway R, Reeves S A

Abstract excerpt

The gene defective in Huntington's disease encodes a protein, huntingtin, with unknown function. Antisera generated against three separate regions of huntingtin identified a single high molecular weight protein of approximately 320 kDa on immunoblots of human neuroblastoma extracts. The same protein species was detected in human and rat cortex synaptosomes and in sucrose density gradients of vesicle-enriched...

Topics

Animals
Antibody Specificity
Brain
Brain Chemistry
Cell Fractionation
Centrifugation, Density Gradient
Cytoplasm
Dendrites
Humans
Huntingtin Protein
Huntington Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immune Sera

Immunochemistry

Mutation

Nerve Tissue Proteins

Neuroblastoma

Neurons

Nuclear Proteins

Source

Open in PubMed

Identifiers

PMID: 7748555
DOI: 10.1016/0896-6273(95)90346-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7748555-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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