Article
Biological properties of Ret with cysteine mutations correlate with multiple endocrine neoplasia type 2A, familial medullary thyroid carcinoma, and Hirschsprung's disease phenotype.
Cancer research - 15 Jul 1997
Ito S, Iwashita T, Asai N, Murakami H, Iwata Y, Sobue G, Takahashi M
Abstract excerpt
We investigated the transforming activity of the ret proto-oncogene with a mutation in cysteine 609, 611, 618, 620, 630, or 634 detected in patients with multiple endocrine neoplasia type 2A (MEN 2A), familial medullary thyroid carcinoma (FMTC), or Hirschsprung's disease. Of these cysteine mutations, codon 634 mutations are known to be correlated with the development of MEN 2A, whereas codon 609, 618, or 620...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.