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Article

A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins.

The Journal of biological chemistry - 26 Jul 1996

Asai N, Murakami H, Iwashita T, Takahashi M

Abstract excerpt

Germ line mutations of the ret proto-oncogene are associated with the development of three dominantly inherited neoplastic disorders, multiple endocrine neoplasia (MEN) 2A, MEN 2B, and familial medullary thyroid carcinoma. It has been demonstrated that the mutations result in constitutive activat...

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Identifiers

PMID: 8663426
DOI: 10.1074/jbc.271.30.17644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8663426-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins.PMID 8663426Read ↗

Molecular mechanisms of development of multiple endocrine neoplasia 2 by RET mutations.Semantic proximity Read ↗

The role of amino acids surrounding tyrosine 1062 in ret in specific binding of the shc phosphotyrosine-binding domain.Semantic proximity Read ↗

RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2.Semantic proximity Read ↗

Deciphering adaptor specificity in GFL-dependent RET-mediated proliferation and neurite outgrowth.Semantic proximity Read ↗

Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction.Semantic proximity Read ↗

The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret.Semantic proximity Read ↗

Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase.Semantic proximity Read ↗

Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade.Semantic proximity Read ↗

Identification of Shc docking site on Ret tyrosine kinase.Semantic proximity Read ↗

Differential effects of leukocyte common antigen-related protein on biochemical and biological activities of RET-MEN2A and RET-MEN2B mutant proteins.Semantic proximity Read ↗

A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia.Semantic proximity Read ↗

Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice.Semantic proximity Read ↗

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