Article
Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region.
Oncogene - 26 Feb 1998
Nakamura H, Yoshida M, Tsuiki H, Ito K, Ueno M, Nakao M, Oka K, Tada M, Kochi M, Kuratsu J, Ushio Y, Saya H
Abstract excerpt
The loss of chromosome 10 is the most frequent genetic alteration found in malignant astrocytomas. In particular, the long arm of chromosome 10 was previously reported to have two or more common deletion regions where tumor suppressor genes may be located. In this study, we performed deletion map...
Topics
- Amino Acid Sequence
- Animals
- Astrocytoma
- Blotting, Northern
- Brain Neoplasms
- Chromosome Mapping
- Chromosomes, Human, Pair 10
- DNA, Neoplasm
- DNA, Satellite
- Drosophila
- Genes, erbB-2
- Glioblastoma
- Glioma
- Humans
- Loss of Heterozygosity