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Article

A single amino acid substitution in nonstructural protein 3A can mediate adaptation of foot-and-mouth disease virus to the guinea pig.

Journal of virology - 1 Apr 2001

Núñez J I, Baranowski E, Molina N, Ruiz-Jarabo C M, Sánchez C, Domingo E, Sobrino F

Abstract excerpt

The genetic changes selected during the adaptation of a clonal population of foot-and-mouth disease virus (FMDV) to the guinea pig have been analyzed. FMDV clone C-S8c1 was adapted to the guinea pig by serial passage in the animals until secondary lesions were observed. Analysis of the virus directly recovered from the lesions developed by the animals revealed the selection of variants with two amino acid...

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Source

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Identifiers

PMID: 11264387
DOI: 10.1128/JVI.75.8.3977-3983.2001
PMCID: PMC114889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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