Article
Genetic and phenotypic variability during replication of foot-and-mouth disease virus in swine.
Virology - 1 Dec 1990
Carrillo C, Plana J, Mascarella R, Bergadá J, Sobrino F
Abstract excerpt
A plaque-purified preparation of foot-and-mouth disease virus (FMDV) of serotype C1 (C-S8c1-1), grown in cell culture, was used to infect nonimmunized pigs. No variant genomes were detected in the average populations of 50 viruses isolated from infected animals by direct RNA sequencing of the carboxy-terminal half of the VP1 gene. However, a mutant with altered phenotypic properties was present in low proportion...
Topics
- Animals
- Antibodies, Monoclonal
- Antibodies, Viral
- Antigens, Viral
- Aphthovirus
- Cell Line
- Cricetinae
- Epitopes
- Foot-and-Mouth Disease
- Gene Frequency
- In Vitro Techniques