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Article

Comparative dynamics of Japanese encephalitis virus adaptation in porcine macrophages and insect cells.

Virology journal - 27 Jun 2026

Marti Andrea, Nater Alexander, Magalhaes Jenny Pego, Donzé Noelle, Gerber Markus, Almeida Lea, Liniger Matthias, Chenaux Sandra, Ruggli Nicolas, Alnaji Fadi G, Vignuzzi Marco, Garcia-Nicolas Obdulio, Summerfield Artur

Abstract excerpt

BACKGROUND: Japanese encephalitis virus (JEV) is a zoonotic mosquito-borne Orthoflavivirus that circulates primarily in birds and pigs. Previous observations of vector-free transmission between pigs indicates the possibility of single-host cycling in swine. Therefore, the aim of this work was to investigate the evolutionary pressure of single host cycling using a relevant primary cell culture model. METHODS: To...

Read the complete abstract on PubMed

Topics

Animals
Encephalitis Virus, Japanese
Swine
Macrophages
Aedes
Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Serial Passage

High-Throughput Nucleotide Sequencing

Selection, Genetic

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 42365317
DOI: 10.1186/s12985-026-03231-0
PMCID: PMC13573486

Genes

C6

Provenance

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