Article
Glutathione-S-transferase family of enzymes.
Mutation research - 1 Oct 2001
Strange R C, Spiteri M A, Ramachandran S, Fryer A A
Abstract excerpt
The loci encoding the glutathione-S-transferase (GST) enzymes comprise a large supergene family located on at least seven chromosomes. The function of the GST enzymes has traditionally been considered to be the detoxication of electrophiles by glutathione conjugation. A wide variety of endogenous (e.g. by-products of reactive oxygen species activity) and exogenous (e.g. polycyclic aromatic hydrocarbons)...
Topics
- Asthma
- Carcinoma, Basal Cell
- Genetic Predisposition to Disease
- Glutathione S-Transferase pi
- Glutathione Transferase
- Humans
- Isoenzymes
- Polymorphism, Genetic
- Skin Neoplasms
