Article
p53 mutation and detection of p53 protein expression in oral leukoplakia and oral squamous cell carcinoma.
Anticancer research - 1 Jan 2000
Ries J C, Schreiner D, Steininger H, Girod S C
Abstract excerpt
In many studies the detection of p53 protein by immunohistochemistry (IHC) with one antibody is assumed to be consistent with a mutation of the gene. To determine the correlation of protein detection by immunohistochemistry and gene mutation, paraffin embedded specimens of 60 oral leukoplakias (OL) and 73 oral squamous cell carcinomas (OSCC) were analysed by IHC with two different antibodies (Do7; Pab 1801),...
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