Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase.

Journal of cell science - 1 Jul 2004

Wherlock Matthew, Gampel Alexandra, Futter Clare, Mellor Harry

Abstract excerpt

The Rho family of small GTPases play a pivotal role in the dynamic regulation of the actin cytoskeleton. Recent studies have suggested that these signalling proteins also have wide-ranging functions in membrane trafficking pathways. The Rho family member RhoB was shown to localise to vesicles of the endocytic compartment, suggesting a potential function in regulation of endocytic traffic. In keeping with this, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkyl and Aryl Transferases
Share to Cytoskeleton
Share to Endosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Farnesyltranstransferase

Share to Lysosomes

Share to Microscopy, Electron, Transmission

Share to Platelet Membrane Glycoproteins

Share to Protein Prenylation

Source

Identifiers

PMID: 15226397
DOI: 10.1242/jcs.01193

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase.PMID 15226397Read ↗

PRK1 is targeted to endosomes by the small GTPase, RhoB.Semantic proximity Read ↗

Isoprenylation of RhoB is necessary for its degradation. A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway.Semantic proximity Read ↗

Cell Growth Inhibition by Farnesyltransferase Inhibitors Is Mediated by Gain of Geranylgeranylated RhoBSemantic proximity Read ↗

RhoB in cancer suppression.Semantic proximity Read ↗

RhoB-dependent modulation of postendocytic traffic in polarized Madin-Darby canine kidney cells.Semantic proximity Read ↗

Approaches to analyze the role of Rab GTPases in endocytic trafficking of epidermal growth factor receptor (EGFR).Semantic proximity Read ↗

Geranylgeranylated, but not farnesylated, RhoB suppresses Ras transformation of NIH-3T3 cells.Semantic proximity Read ↗

Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease.Semantic proximity Read ↗

Met endosomal signalling: in the right place, at the right time.Semantic proximity Read ↗

RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells.Semantic proximity Read ↗

Gab1 signaling is regulated by EGF receptor sorting in early endosomes.Semantic proximity Read ↗

Farnesylated proteins as anticancer drug targets: from laboratory to the clinic.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.