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Article

Expression of mammalian Rab Escort protein-1 and -2 in yeast Saccharomyces cerevisiae.

Protein expression and purification - 1 Oct 2002

Sidorovitch Vadim, Niculae Anca, Kan Natalia, Ceacareanu Alice-Corina, Alexandrov Kirill

Abstract excerpt

Rab GTPases are post-translationally geranylgeranylated on their C-terminal cysteines by Rab geranylgeranyl transferase (RabGGTase) and this modification is essential for their biological activity. Rab Escort Protein (REP) is a molecular chaperone that assists in the prenylation reaction carried out by RabGGTase. Mutations in the REP-1 gene lead to progressive retinal degradation and blindness in humans. Despite...

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Identifiers

PMID: 12356470
DOI: 10.1016/s1046-5928(02)00506-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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