Article
Streptococcal Cysteine Protease-Mediated Cleavage of Desmogleins Is Involved in the Pathogenesis of Cutaneous Infection.
Frontiers in cellular and infection microbiology - 1 Jan 2018
Sumitomo Tomoko, Mori Yasushi, Nakamura Yuumi, Honda-Ogawa Mariko, Nakagawa Seitaro, Yamaguchi Masaya, Matsue Hiroyuki, Terao Yutaka, Nakata Masanobu, Kawabata Shigetada
Abstract excerpt
Streptococcus pyogenes is responsible for a wide variety of cutaneous infections ranging from superficial impetigo to fulminant invasive necrotizing fasciitis. Dysfunction of desmosomes is associated with the pathogenesis of cutaneous diseases. We identified streptococcal pyrogenic exotoxin B (SpeB) as a proteolytic factor that cleaves the extracellular domains of desmoglein 1 and 3. In an epicutaneous infection...
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