Article
Regulation of hly expression in Listeria monocytogenes by carbon sources and pH occurs through separate mechanisms mediated by PrfA.
Infection and immunity - 1 Aug 1998
Behari J, Youngman P
Abstract excerpt
Expression of the PrfA-controlled virulence gene hly (encoding the pore-forming cytolysin listeriolysin) is under negative regulation by readily metabolized carbon sources in Listeria monocytogenes. However, the hyperhemolytic strain NCTC 7973 exhibits deregulated hly expression in the presence o...
Topics
- Alleles
- Amino Acid Sequence
- Bacterial Proteins
- Bacterial Toxins
- Carbohydrate Metabolism
- Carbon
- Gene Expression Regulation, Bacterial
- Genes, Reporter
- Glucuronidase
- Heat-Shock Proteins
- Hemolysin Proteins
- Hydrogen-Ion Concentration
- Listeria monocytogenes
- Molecular Sequence Data
- Peptide Termination Factors
- Recombinant Fusion Proteins
- Sequence Homology, Amino Acid
- Trans-Activators