Article
Spontaneous Loss of Virulence in Natural Populations of Listeria monocytogenes.
Infection and immunity - 1 Nov 2017
Maury Mylène M, Chenal-Francisque Viviane, Bracq-Dieye Hélène, Han Lei, Leclercq Alexandre, Vales Guillaume, Moura Alexandra, Gouin Edith, Scortti Mariela, Disson Olivier, Vázquez-Boland José A, Lecuit Marc
Abstract excerpt
The pathogenesis of Listeria monocytogenes depends on the ability of this bacterium to escape from the phagosome of the host cells via the action of the pore-forming toxin listeriolysin O (LLO). Expression of the LLO-encoding gene (hly) requires the transcriptional activator PrfA, and both hly and prfA genes are essential for L. monocytogenes virulence. Here, we used the hemolytic activity of LLO as a phenotypic...
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