Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Humanization of murine monoclonal antibodies through variable domain resurfacing.

1 Feb 1994

Abstract excerpt

Two murine monoclonal antibodies, N901 (anti-CD56) and anti-B4 (anti-CD19), were humanized by a process we call "resurfacing." A systematic analysis of known antibody structures has been used to determine the relative solvent accessibility distributions of amino acid residues in murine and human antibody variable (Fv) regions and has shown that the sequence alignment positions of surface amino acids for human and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glycosylation and Glycoproteins Research
Share to Monoclonal and Polyclonal Antibodies Research
Share to RNA and protein synthesis mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8302875
DOI: 10.1073/pnas.91.3.969

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Humanization of murine monoclonal antibodies through variable domain resurfacing.PMID 8302875Read ↗

Structure guided homology model based design and engineering of mouse antibodies for humanizationSemantic proximity Read ↗

Antibody humanization methods – a review and updateSemantic proximity Read ↗

Engineering Fully Human Monoclonal Antibodies from Murine Variable RegionsSemantic proximity Read ↗

Humanization of rabbit monoclonal antibodies via grafting combined Kabat/IMGT/Paratome complementarity-determining regions: Rationale and examplesSemantic proximity Read ↗

A phage display approach for rapid antibody humanization: Designed combinatorial V gene librariesSemantic proximity Read ↗

Humanization of antibodies using a machine learning approach on large-scale repertoire dataSemantic proximity Read ↗

Antibody Humanization Using Monovalent Phage DisplaySemantic proximity Read ↗

Humanization of antibodies using heavy chain complementarity-determining region 3 grafting coupled with in vitro somatic hypermutation.Semantic proximity Read ↗

VH-VL orientation prediction for antibody humanization candidate selection: A case studySemantic proximity Read ↗

A molecular immunology approach to antibody humanization and functional optimizationSemantic proximity Read ↗

Humanization of Predicted T-Cell Epitopes Reduces the Immunogenicity of Chimeric Antibodies: New Evidence Supporting a Simple MethodSemantic proximity Read ↗

Reliable energy-based antibody humanization and stabilizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.