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Article

Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse.

Oncogene - 9 Jul 1998

Vooijs M, van der Valk M, te Riele H, Berns A

Abstract excerpt

The yeast-derived Flp-frt site-specific DNA recombination system was used to achieve pituitary-specific inactivation of the retinoblastoma (Rb) tumor suppressor gene. Whereas mice carrying only frt sites in both alleles of Rb remain tumor free, tumorigenesis ensues when the Flp recombinase is expressed. The rate of tumorigenesis in these mice depends both on the expression level of the Flp recombinase and on the...

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Identifiers

PMID: 9671308
DOI: 10.1038/sj.onc.1202169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse.PMID 9671308Read ↗

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Cre-mediated somatic site-specific recombination in miceSemantic proximity Read ↗

Quantitative effects of the retinoblastoma gene on mouse development and tissue-specific tumorigenesis.Semantic proximity Read ↗

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E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas.Semantic proximity Read ↗

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