Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse.

doi:10.1038/sj.onc.1202169

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Article

Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse.

Oncogene - 9 Jul 1998

Vooijs M, van der Valk M, te Riele H, Berns A

Abstract excerpt

The yeast-derived Flp-frt site-specific DNA recombination system was used to achieve pituitary-specific inactivation of the retinoblastoma (Rb) tumor suppressor gene. Whereas mice carrying only frt sites in both alleles of Rb remain tumor free, tumorigenesis ensues when the Flp recombinase is exp...

Topics

Alleles
Animals
Apoptosis
Cell Division
Cell Line
DNA Nucleotidyltransferases
Disease Progression
Female
Gene Deletion
Gene Expression Regulation, Neoplastic
Genes, Retinoblastoma
Male
Mice
Mice, Transgenic
Pituitary Gland
Pituitary Neoplasms
Rabbits
Rats

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