Article
Binding of the 60-kDa Ro autoantigen to Y RNAs: evidence for recognition in the major groove of a conserved helix.
RNA (New York, N.Y.) - 1 Jul 1998
Green C D, Long K S, Shi H, Wolin S L
Abstract excerpt
The 60-kDa Ro autoantigen is normally complexed with small cytoplasmic RNAs known as Y RNAs. In Xenopus oocytes, the Ro protein is also complexed with a large class of variant 5S rRNA precursors that are folded incorrectly. Using purified baculovirus-expressed protein, we show that the 60-kDa Ro...
Topics
- Animals
- Autoantigens
- Base Sequence
- Binding Sites
- Conserved Sequence
- Molecular Probes
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Protein Binding
- RNA
- RNA, Small Cytoplasmic
- Recombinant Proteins
- Ribonucleoproteins
- Sequence Deletion
- Xenopus