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Article

Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins

1 Jan 2000

Abstract excerpt

Human Ro ribonucleoproteins (RNPs) are autoantigenic particles of unknown function(s) that consist of a 60-kDa protein (Ro60) associated with one hY RNA (hY1-5). Using a modified yeast three-hybrid system, named RNP interaction trap assay (RITA), we cloned a novel Ro RNP-binding protein (RoBPI), based on its property to interact in vivo in yeast with an RNP complex made of recombinant Ro60 (rRo60) protein and hY5...

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PMID: 10668799
DOI: 10.1017/s1355838200990277

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