Regulation of TNFalpha and TGFbeta-1 gene transcription by HIV-1 Tat in CNS cells.

doi:10.1016/s0165-5728(98)00044-7

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Article

Regulation of TNFalpha and TGFbeta-1 gene transcription by HIV-1 Tat in CNS cells.

Journal of neuroimmunology - 1 Jul 1998

Sawaya B E, Thatikunta P, Denisova L, Brady J, Khalili K, Amini S

Abstract excerpt

Tat is a transcription transactivator produced by the human immunodeficiency virus type 1 (HIV-1) at the early phase of infection and plays a critical role in the expression and replication of the viral genome. This 86 amino acid protein, which can be secreted from the infected cells, has the abi...

Topics

Brain
Gene Products, tat
HIV-1
Humans
Jurkat Cells
Mutation
RNA, Messenger
Transcription, Genetic
Transcriptional Activation
Transforming Growth Factor beta
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha
tat Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed

Identifiers

PMID: 9670843
DOI: 10.1016/s0165-5728(98)00044-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9670843-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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